Cosmelan
The mesoestetic treatment for melasma and dark spots that keep coming back.
One of the leading depigmenting methods. With the Cosmelan home pack you can do the complete treatment at home. And if you have already had Cosmelan done in a clinic, you will also find the cream to continue it here.
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Good to know
- Everything in one pack, depigmenting cream, repair cream and tinted sunscreen
- Gradual results you will see over months
- We support you on WhatsApp before and during the treatment
Which dark spots it is for
Cosmelan is an intensive treatment. It makes sense when a spot is persistent or keeps coming back.
Melasma
Symmetrical patches on the cheeks, forehead or upper lip. Internal factors such as hormones and genetics play a part, as do external ones like sun, heat, pollution or some medications, including contraceptives. It is the main indication.
Stubborn spots
Spots that have not improved with other depigmenting products or that come back every time the sunny weather returns.
Mild spots or uneven tone?
You don't need such an intensive treatment. Our dark spot guide explains which option suits you best.
See the dark spot guide →How the at-home treatment works
Results depend more on consistency than intensity. These are its three stages.
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First weeks
Start
Cosmelan 2 as directed, melan recovery to soothe the skin and Mesoprotech every morning. It is normal for your skin to peel, turn red, itch or sting. These are signs the treatment is working. If at any point you find it hard to tolerate or notice any adverse effect, message us and we will look at it with you.
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The following months
Correct
The spot gradually fades. If you need to skip an application now and then, that's fine, the treatment may take a little longer. What you can't skip is your sunscreen.
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Afterwards
Maintain
Once the spot has faded, the goal becomes stopping it from coming back. We will set you up with a good maintenance skincare routine, always with daily sun protection.
Cosmelan home pack or Cosmelan 2
It's the most common question. The difference is whether you are starting the treatment or already in the middle of it.
Cosmelan home pack
Complete at-home treatmentIncludes cosmelan 2, the depigmenting cream, melan recovery to soothe and repair the skin, and Mesoprotech melan 130+, the tinted sunscreen.
- The option for starting the treatment at home
- For around €70 more than cosmelan 2 alone, you also get the repair cream and the sunscreen

Cosmelan 2
Just the depigmenting creamThe method's daily cream. It is what works on the spot during the months of treatment.
- If you have already had Cosmelan in a clinic and need to continue
- To restock when the jar runs out
Without sun protection, it does not work
This part is non-negotiable. The sun, even on cloudy days and in winter, reactivates melanin production and can undo months of work in a few weeks. The home pack already includes Mesoprotech melan 130+, whose tint also protects against visible light. Apply it every morning and reapply during the day if you are outdoors.
Not sure if Cosmelan is right for you?
If this is your first depigmenting treatment or you are torn between the pack and the cream, message us before buying and we will guide you based on your skin.
FAQ
How long before I see results?
Pigmentation results are measured in months, not days. The change is gradual and consistency matters more than intensity. Applying it properly every day for months works better than starting very strong and giving up.
Can I do the treatment without going to a clinic?
Yes, the Cosmelan home pack is designed to be used at home. If you are not sure whether your spot needs Cosmelan or a gentler depigmenting product, message us before buying.
Can melasma be treated?
Yes, it can be treated and improved a lot, but it does not go away for good. It tends to come back with sun exposure or hormonal changes, which is why the maintenance stage is not optional.
Can I do the treatment in summer?
It depends more on you than on the calendar. If you are going to protect your skin properly, with SPF every morning reapplied during the day, a cap or hat and avoiding the midday sun, or if you simply do not sunbathe, you can. If you are heading to the beach and know you will not follow the routine, it is not the right time, as unprotected exposure can make spots come back or darken. That is why, in most cases, we recommend starting in autumn.
Can I combine it with retinol or acids?
No. During the treatment, Cosmelan should not be combined with retinol or other acids or exfoliants, because your skin is already working hard and adding them would irritate it further. What it needs is the opposite, a simple routine that hydrates it and helps repair its barrier, like melan recovery, which is already in the pack. If you have questions about any product in your routine, message us before using it.
How does shipping work?
We prepare orders from our centre in Barcelona. You will find up-to-date delivery times and costs in the store shipping policy.
Cosmelan® is a registered trademark of mesoestetic Pharma Group. Cosmetic products are not medicines, and this page is not medical advice or a substitute for assessment by a healthcare professional. If a spot has appeared recently, changes shape, size or colour, or bleeds, see a dermatologist before starting any cosmetic treatment. If you are pregnant, breastfeeding or undergoing dermatological treatment, check with a professional before starting any depigmenting routine. Results vary depending on the type of spot, skin phototype and how consistently you apply the products and sun protection.